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Abstract #1128

In vivo high resolution multifrequency MR elastography of neuro tumors compared to single cell mechanical properties

Ingolf Sack 1 , Anatol Fritsch 2 , Steve Pawlizak 2 , Martin Reiss-Zimmermann 3 , Karl-Titus Hoffmann 3 , Felix Arlt 4 , Wolf Mller 5 , Jing Guo 1 , Jrgen Braun 6 , and Josef Ks 2

1 Radiology, Charit - Universittsmedizin Berlin, Berlin, Berlin, Germany, 2 Physics and Earth Sciences, University of Leipzig, Saxony, Germany, 3 Department of Neuroradiology, University Hospital, University of Leipzig, Saxony, Germany, 4 Department of Neurosurgery, University Hospital, University of Leipzig, Saxony, Germany, 5 Department of Neuropathology, University Hospital, University of Leipzig, Saxony, Germany, 6 Department of Medical Informatics, Charit - Universittsmedizin Berlin, Berlin, Germany

This study aims to bridge the gap between micro and macro scales of viscoelastic tissue properties in tumors. High resolution MRE was applied within clinical routine exams for measuring in-vivo viscoelastic properties of 7 cerebral tumors of different entity. Single cell viscoelastic properties of the same tumors were measured after surgery by the optical stretcher. We observed a significant correlation between in-vivo MRE and single cell elasticity with marked softening in high-WHO grade tumors. Thus, cellular mechanics is an important marker for in-vivo tissue viscoelasticity by which tumors can be staged in the future using MRE.

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