Abstract #1134
MRI Functional Parameters in Breast Cancer:T2*, ADC and Contrast Agent Uptake
Evanthia Kousi 1 , Maria A. Schmidt 1 , Marco Borri 1 , Cheryl Richardson 2 , Georgina Hopkinson 2 , Elizabeth A.M. O'Flynn 1 , Robin M. Wilson 2 , Steven Allen 2 , Romney J.E. Pope 2 , and Martin O. Leach 1
1
CR-UK and EPSRC Imaging Centre, Royal
Marsden NHS Foundation Trust and Institute of Cancer
Reasearch, Sutton, Surrey, United Kingdom,
2
Department
of Radiology, Royal Marsden NHS Foundation Trust,
Chelsea, London, United Kingdom
T2* relaxation time has been proposed as an imaging
biomarker to evaluate hypoxia associated with tumour
grade and therapeutic response. In this study, we
explore the relationship between T2*, ADC and contrast
agent uptake. Substantial variations for all functional
parameters detected within tumours. Considerable
inter-subject variability observed in the association
between T2* and ADC for breast tumours. Less variability
observed in the association between T2* and contrast
uptake. Considering all patients, T2* and ADC correlated
weakly and no correlation observed between T2* and
contrast uptake. Our results suggest that T2* is an
independent parameter and may provide new clinical
information.
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