Modelling tissue microstructure in bone metastases from prostate cancer using VERDICT MRI
Colleen Bailey 1 , Eleftheria Panagiotaki 1 , Nina Tunariu 2 , Matthew R Orton 3 , Veronica A Morgan 3 , Thorsten Feiweier 4 , David J Hawkes 1 , Martin O Leach 3 , David J Collins 3 , and Daniel C Alexander 1
Centre for Medical Image Computing,
University College London, London, United Kingdom,
Royal Marsden NHS Foundation Trust and Institute of
Cancer Research, Sutton, United Kingdom,
and EPSRC Cancer Imaging Centre, Institute of Cancer
Research and Royal Marsden NHS Foundation Trust, London,
Sector, Siemens AG, Erlangen, Germany
Bone metastases in men with advanced prostate cancer
were examined by diffusion MRI with varying diffusion
times and gradient strengths. Data were fitted to
3-compartment models of diffusion that included a
perfusion compartment, an extracellular compartment and
an intracellular spherically-restricted compartment.
Data showed variation for points with the same b-value
but different diffusion time and were better explained
by a model incorporating restriction than either
conventional ADC or 2- or 3-compartment models with free
diffusion. Model parameters indicated a low perfusion
fraction (<10%), intracellular volume fraction 0.22-0.56
and a cell radius between 4.7-9.9 m.
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