Bi-exponential diffusion analysis in normal prostate and prostate cancer: transition zone and peripheral zone considerations
Thiele Kobus 1,2 , Andriy Fedorov 1 , Clare Tempany 1 , Robert Mulkern 3 , Ruth Dunne 1 , and Stephan E. Maier 1
Radiology, Brigham and Women's Hospital,
Boston, Massachusetts, United States,
Radboud UMC, Nijmegen, Netherlands,
Children's Hospital, Boston, Massachusetts, United
We investigated the performance of the bi-exponential
fit for extended b-factor DWI (b=0 to 3500 s/mm
in discriminating between different tissues in prostate
imaging. The means of the fitted parameters, ADC
were significantly different between normal tissue (PZ
and TZ) and tumor tissue in both PZ and TZ. There was
also a difference for f
normal PZ and TZ (p<0.001). No differences in the
parameters were found between tumors in the PZ and TZ.
The increase of f
tumor tissue might represent the occupation of the
luminal space by tumor cells.
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