In Vivo Sodium Imaging of Human Prostate Cancer
Justin Charles Peterson 1 , Adam Farag 2 , Trevor Szekeres 2 , Eli Gibson 2,3 , Aaron D Ward 2,3 , Joseph Chin 4 , Stephen Pautler 5 , Glenn Bauman 4 , Cesare Romagnoli 4 , Robert Bartha 1,2 , and Timothy J Scholl 1,2
Medical Biophysics, Western University,
London, Ontario, Canada,
Research Institute, Ontario, Canada,
Engineering, Western University, Ontario, Canada,
Health Sciences Centre, Ontario, Canada,
Joseph's Health Care, Ontario, Canada
Prostate cancer (PCa) is the most common malignancy in
men. Currently, a combination of multi-parametric MR
diffusion-weighted, and dynamic contrast enhanced
imaging, is used clinically but often provides
insufficient information to determine the malignancy of
a lesion. Previous studies have shown increased MRI
measured tissue sodium concentration (TSC) in brain and
breast cancer. In this report we demonstrate
MRI in patients with PCa. Using this proposed method TSC
data was registered to histopathology and analyzed.
These preliminary data show a positive correlation
between tumor grade and TSC within the prostate.
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