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Abstract #1168

Radiogenomics of Prostate Cancer: Association Between Quantitative Multi-Parametric MRI Features and PTEN Expression

Aytekin Oto 1 , David VanderWeele 2 , Yulei Jiang 1 , Stephanie Maria McCann 1 , Xiaobing Fan 1 , Jianing Wang 1 , and Tatjana Antic 3

1 Radiology, The University of Chicago Medicine, Chicago, IL, United States, 2 Internal Medicine, The University of Chicago Medicine, Chicago, IL, United States, 3 Pathology, The University of Chicago Medicine, Chicago, IL, United States

Multi-parametric MRI (Mp-MRI) is playing an increasing role in the detection, staging and localization of Pca. Determination of the cancer aggressiveness by Mp-MRI has been addressed in several studies and significant correlations between quantitative MRI parameters (such as apparent diffusion coefficient [ADC] and ktrans) and Gleason score have been reported. However, to our knowledge, no study thus far has investigated associations between quantitative Mp-MRI parameters and genomic markers in Pca.

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