Abstract #1216
Whole spine vertebral bone marrow proton density fat fraction mapping: anatomical variation and gender-specific reference database
Thomas Baum 1 , Samuel P Yap 1 , Michael Dieckmeyer 1 , Stefan Ruschke 1 , Holger Eggers 2 , Hendrik Kooijman 3 , Ernst J Rummeny 1 , Jan S Bauer 4 , and Dimitrios C Karampinos 1
1
Department of Radiology, Klinikum rechts der
Isar, Technische Universitaet Muenchen, Munich, Germany,
2
Philips
Research Laboratory, Hamburg, Germany,
3
Philips
Healthcare, Hamburg, Germany,
4
Section
of Neuroradiology, Klinikum rechts der Isar, Technische
Universitaet Muenchen, Munich, Germany
There is a growing interest in vertebral bone marrow
tissue as anatomical compartment that contributes to
systemic and bone metabolism. Bone marrow adiposity is
associated with visceral adipose tissue and HbA1c values
in women with type 2 diabetes mellitus, chemotherapy and
radiation treatment-induced bone marrow damage, and bone
loss pathophysiology. Chemical shift encoding-based
water-fat imaging has been emerging to measure vertebral
bone marrow proton density fat fraction (PDFF). In this
study, we assessed the anatomical variation of PDFF over
the whole spine and provided a reference database of
PDFF values of young, healthy subjects, which has not
been established yet.
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