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Abstract #1216

Whole spine vertebral bone marrow proton density fat fraction mapping: anatomical variation and gender-specific reference database

Thomas Baum 1 , Samuel P Yap 1 , Michael Dieckmeyer 1 , Stefan Ruschke 1 , Holger Eggers 2 , Hendrik Kooijman 3 , Ernst J Rummeny 1 , Jan S Bauer 4 , and Dimitrios C Karampinos 1

1 Department of Radiology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany, 2 Philips Research Laboratory, Hamburg, Germany, 3 Philips Healthcare, Hamburg, Germany, 4 Section of Neuroradiology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany

There is a growing interest in vertebral bone marrow tissue as anatomical compartment that contributes to systemic and bone metabolism. Bone marrow adiposity is associated with visceral adipose tissue and HbA1c values in women with type 2 diabetes mellitus, chemotherapy and radiation treatment-induced bone marrow damage, and bone loss pathophysiology. Chemical shift encoding-based water-fat imaging has been emerging to measure vertebral bone marrow proton density fat fraction (PDFF). In this study, we assessed the anatomical variation of PDFF over the whole spine and provided a reference database of PDFF values of young, healthy subjects, which has not been established yet.

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