Frequency dependant shear properties of bovine ex vivo intervertebral disc.
Delphine Perie 1 , Pierre-Francois Beauchemin 1 , Phil Bayly 2 , Joel R Garbow 2 , John Schmidt 2 , Ruth Okamoto 2 , and Farida Cheriet 1
Mechanical Engineering, Polytechnique
Montreal, Montreal, Quebec, Canada,
Engineering and Materials Science, Washington University
in St. Louis, Saint Louis, Missouri, United States
Aging and degeneration have been shown to be associated
with changes in intervertebral disc mechanical
properties, generating interest in the use of mechanical
properties to establish early biomarkers for the
degenerative cascade. This study demonstrated that
global mechanical characterization of the intervertebral
disc, including both nucleus pulposus and annulus
fibrosus, was possible with high frequency needle
magnetic resonance elastography. The advantages and
limitations of different approaches to the inversion
problem in the intervertebral disc were also determined.
The developed method could be adapted in vivo to assess
the contribution of osmotic pressure to the mechanical
behavior of the intervertebral disc.
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