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Abstract #1225

Dynamic measurement of muscle R2, R2' and R2* during ischemia and reactive hyperemia

Chengyan Wang 1 , Rui Zhang 2 , Xiaodong Zhang 3 , He Wang 4 , Kai Zhao 3 , Jue Zhang 1,2 , Xiaoying Wang 1,3 , and Jing Fang 1,2

1 Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, Beijing, China, 2 College of Engineering, Peking University, Beijing, China, 3 Department of Radiology, Peking University First Hospital, Beijing, China, 4 Philips Research China, Shanghai, Shanghai, China

Muscle BOLD MRI has been used to infer small vessel function following arterial occlusion, the infusion of vasoactive compounds and to study vascular function in peripheral artery disease. BOLD R2* is a summation of irreversible (R2) and reversible(R2) relaxation rates (R2*=R2+R20). It has been suggested that R2 is sensitive to many physiological perturbations, including tissue water content, inflammation and changes in tissue oxygenation. However, R2 is linearly dependent on tissue oxygenation. Therefore, R2 is able to provide a more specific and direct evaluation of muscle oxygenation. Muscle BOLD MRI has been used to infer small vessel function following arterial occlusion, the infusion of vasoactive compounds and to study vascular function in peripheral artery disease. BOLD R2* is a summation of irreversible (R2) and reversible(R2) relaxation rates (R2*=R2+R20). It has been suggested that R2 is sensitive to many physiological perturbations, including tissue water content, inflammation and changes in tissue oxygenation. However, R2 is linearly dependent on tissue oxygenation. Therefore, R2 is able to provide a more specific and direct evaluation of muscle oxygenation.

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