MRI characterization of individual muscles in patients with sporadic inclusion body myositis (sIBM) using a semi-automatic segmentation approach
Didier Laurent 1 , Attila Nagy 2 , Steve Pieper 2 , Harlem Gongxeka 1 , Celeste Pretorius 1 , and Stefan Baumann 1
Biomarker Department, Novartis, Basel,
Inc, Cambridge, Ma, United States
A 3D semi-automated segmentation approach was developed
and validated for quick and accurate determination of
individual thigh muscle volumes from magnetic resonance
(MR) image series of both healthy individuals and
patients with sporadic inclusion body myositis (sIBM).
Specific muscles of sIBM patients displayed clear signs
of atrophy, more so in the anterior compartment of the
thigh, along with up to 50% of infiltrated fat, which
might explain propensity of these patients to loose
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