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Abstract #1234

Time-dependent diffusion as a biomarker for rotator cuff atrophy

Gregory Lemberskiy 1,2 , Dmitry Novikov 1 , Mary Bruno 1 , Els Fieremans 1 , and Soterios Gyftopoulos 1

1 Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, 2 Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, NY, United States

We show that modeling myofiber diameter using time dependent diffusion is feasible in the rotator cuff by comparing the diameters of the infraspinatus and supraspinatus across 10 shoulders. Fiber diameters in 2 clinical patients with full thickness tears were quantified longitudinally within 2 weeks prior to surgery and 3 months after surgery. Our method showed a systematic drop in fiber diameter after 3 months indicating that the model could serve as a biomarker for atrophy consequently and surgical outcome.

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