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Abstract #1238

Quantitative Measurement of Blood Flow in Contracting Rat Muscle Using MR Angiography

Anne Tonson 1,2 , Jonathan Kasper 1,2 , Ronald A Meyer 3,4 , and Robert W Wiseman 2,3

1 Physiology Department, Michigan State University, East Lansing, MI, United States, 2 Biomedical Imaging Research Center, Michigan State University, East Lansing, MI, United States, 3 Physiology and Radiology Departments, Michigan State University, East Lansing, MI, United States, 4 Biomedical Imaging Research Center, East Lansing, MI, United States

This study aimed to investigate the effect of skeletal muscle workload on local muscle blood flow and the corresponding time-course of flow recovery in the rat hindlimb using 2D_ PC-MRA measurements in the femoral vein. The present results showed a significant increase in flow from baseline in response to contraction regardless of the intensity. The corresponding change was lower for non- fatiguing stimulation (≤1Hz) compared to fatiguing contraction (≥2Hz) for which we also observed a reactive hyperemia. This study shows that MRI-based regional blood flow measurement can be used for the quantitative investigation of post-contraction time-course of flow recovery

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