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Abstract #1277

A metabolic study of normal mouse brain maturation using hyperpolarized 13C

Yiran Chen 1 , Robert Bok 1 , Subramanian Sukumar 1 , Hosung Kim 1 , Xin Mu 1 , Ann Sheldon 1 , A James Barkovich 1 , Donna M Ferriero 1 , and Duan Xu 1

1 University of California San Francisco, San Francisco, CA, United States

In this study, we applied dynamic nuclear polarization (DNP) technique to investigate C1 labeled 13C pyruvate to lactate conversion and T2-weighted MRI for brain volume analysis across maturation in mice in vivo. Normal mice were scanned starting on postnatal day 18 and repeated every 10 days. Lactate level was significantly higher at younger ages, and decreased with increase in age. No significant global brain volume growth was observed after P18.

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