A metabolic study of normal mouse brain maturation using hyperpolarized 13C
Yiran Chen 1 , Robert Bok 1 , Subramanian Sukumar 1 , Hosung Kim 1 , Xin Mu 1 , Ann Sheldon 1 , A James Barkovich 1 , Donna M Ferriero 1 , and Duan Xu 1
University of California San Francisco, San
Francisco, CA, United States
In this study, we applied dynamic nuclear polarization
(DNP) technique to investigate C1 labeled 13C pyruvate
to lactate conversion and T2-weighted MRI for brain
volume analysis across maturation in mice in vivo.
Normal mice were scanned starting on postnatal day 18
and repeated every 10 days. Lactate level was
significantly higher at younger ages, and decreased with
increase in age. No significant global brain volume
growth was observed after P18.
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