Meeting Banner
Abstract #1283

Modulation of resting-state brain networks in newborns by heel prick

Lara Lordier 1 , Frdric Grouiller 2 , Dimitri Van de Ville 2,3 , Ana Sancho Rossignol 4 , Maria Isabel Cordero 4 , Franois Lazeyras 2 , Franois Ansermet 4 , and Petra S. Hppi 1

1 Division of Development and Growth, Department of Pediatrics, University of Geneva, Geneva, Geneva, Switzerland, 2 Department of Radiology and Medical Informatics, Geneva University Hospital, Geneva, Switzerland, 3 Institute of Bioengineering, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland, 4 Division of Child and Adolescent Psychiatry, Department of Pediatrics, University of Geneva, Geneva, Switzerland

Previous studies in adults reported that spontaneous brain activity can be modulated by learning, training, but also by behavioral states, which is supporting the idea that low-frequency BOLD signal fluctuations are modulated by recent experience. We mapped resting state networks (RSNs) in nine newborns and investigate if these low-frequency BOLD signal fluctuations were modified after a heel prick. We observed RSNs similar to those previously found in adults and infants. Furthermore, we showed an increased connectivity between basal ganglia and orbitofrontal components reflecting the integration and modulation of the pain experience.

This abstract and the presentation materials are available to members only; a login is required.

Join Here