Altered tract integrity of the social communication network and its functional correlations in high-functioning autism: a diffusion spectrum imaging (DSI) study
Yu-Chun Lo 1 , Yu-Jen Chen 1 , Yung-Chin Hsu 1 , Susan Shur-Fen Gau 2,3 , and Wen-Yih Isaac Tseng 1,4
Center for Optoelectronic Medicine, National
Taiwan University College of Medicine, Taipei, Taiwan,
Taiwan University College of Medicine, Department of
Psychiatry, Taipei, Taiwan,
of Psychiatry, National Taiwan University Hospital,
Imaging Center, National Taiwan University, Taipei,
Impaired performance in social communication has been
consistently found in autism spectrum disorder (ASD). We
used diffusion spectrum imaging to measure white matter
property of the social communication network, and
investigated its relationships with social communication
and social awareness for 56 ASD and 44 neurotypicals.
ASD showed reduced white matter integrity of the social
communication network as compared to neurotypicals.
Unique correlations were found between white matter
integrity and the social communication ability in ASD.
Our results indicate altered functional and structural
roles of cores of the social communication network in
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