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Abstract #1315

Age-related microstructural changes quantified using myelin water imaging and advanced diffusion MRI

Thibo Billiet 1,2 , Mathieu Vandenbulcke 3 , Burkhard Mdler 4,5 , Ronald Peeters 6 , Thijs Dhollander 7,8 , Hui Zhang 9 , Sabine Deprez 1,2 , Bea RH Van den Bergh 10,11 , Stefan Sunaert 1,2 , and Louise Emsell 1,2

1 Translational MRI, KU Leuven, Leuven, Belgium, 2 Radiology, University Hospitals, Leuven, Belgium, 3 Old Age Psychiatry, KU Leuven, Belgium, 4 Philips Healthcare, Hamburg, Germany, 5 Neurosurgery, University of Bonn, Bonn, Germany, 6 University Hospitals, Leuven, Belgium, 7 Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia, 8 Elektrotechniek - ESAT, KU Leuven, Leuven, Belgium, 9 Computer Science & Centre for Medical Image Computing, University College London, London, United Kingdom, 10 Psychology, Tilburg University, Tilburg, Netherlands, 11 Health Psychology, KU Leuven, Leuven, Belgium

Using a combination of diffusion MRI (DTI/DKI/NODDI) and myelin water imaging, normal development of the brain can be assessed with increased specificity. This study explores signs of normal ageing between the age of 20 and 70.

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