Abstract #1323
Altered antioxidant profile in the healthy elderly occipital and posterior cingulate cortices measured via 7 T 1 H MRS
Malgorzata Marjanska 1 , J. Riley McCarten 2 , Laura S Hemmy 2 , Dinesh K Deelchand 1 , and Melissa Terpstra 1
1
Center for Magnetic Resonance Research,
University of Minnesota, Minneapolis, MN, United States,
2
Minneapolis
VA Medical Center, Geriatric Research and Clinical
Center, MN, United States
Oxidative stress occurs at an early stage of age related
cognitive decline. Ascorbate (Asc, vitamin C) and
glutathione (GSH) are key contributors to the
antioxidant network. We utilized short echo time
1
H
MRS at 7 T to reliably quantify these antioxidant
concentrations in the aging brain in the occipital
cortex and the posterior cingulate cortex, which is
pertinent to the pathology of Alzheimers disease. Asc
was higher and GSH lower in elder subjects in both brain
regions. The Asc difference in the PCC were the most
significant (
p
=
1.8 x 10
-5
). This work has important
implications for ongoing development of antioxidant
based diagnosis, prevention and treatment of cognitive
decline.
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