9
yrs) based on 7T
1
H
2
O
R
1
and
R
2
measurements
and relaxivity models that incorporate terms for both
macromolecular volume fraction and [Fe]. Pial surface
iron maps were prepared and the extent and spatial
distribution of iron in 6 functional networks was
determined. We find that [Fe] varies throughout the
cortex in older individuals and is highest in
frontoparietal and default networks. These findings
suggest that the vulnerability of age-related changes in
these networks may be related to increased iron content.
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