Investigating Task-Based Activation and Functional Connectivity in the White Matter using fMRI at 3 Tesla
Don Marciel Ragot 1,2 , Erin Mazerolle 3 , and J. Jean Chen 1,4
Rotman Research Institute, Baycrest,
Toronto, Ontario, Canada,
Science, University of Toronto, Ontario, Canada,
of Calgary, Ontario, Canada,
Biophysics, University of Toronto, Ontario, Canada
Recent studies have used BOLD to detect white-matter
functional activation in the largest white matter
structures in the brain while subjects are performing
interhemispheric tasks. While these studies lay the
foundation for white-matter fMRI, they also used custom
acquisition techniques unavailable on most scanners.
Also, they report focal brain activity, but do not
assess functional connectivity. In this work, we
investigate the feasibility of detecting white-matter
activation using conventional gradient- or spin-echo EPI
at 3 Tesla. Spin-echo EPI produced robust white-matter
activation in the corpus callosum, but not
gradient-echo. We also demonstrate task-related
white-matter fMRI connectivity using spin-echo EPI.
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