Abstract #1347
ECT-INDUCED STRUCTURAL CHANGES IN THE HUMAN BRAIN; A CASE SERIES
Leif Oltedal 1,2 , Ute Kessler 1,3 , Nathan S White 4 , Hauke Bartsch 5 , Bjarne Hansen 3 , Lars Ersland 6 , Renate Grner 2 , Joshua Kuperman 4 , Dominic Holland 7 , Kenneth Hugdahl 3,8 , Ketil J degaard 1,3 , and Anders M Dale 4,5
1
Department of Clinical Medicine, University
of Bergen, Bergen, Norway,
2
Department
of Radiology, Haukeland University Hospital, Bergen,
Norway,
3
Division
of Psychiatry, Haukeland University Hospital, Bergen,
Norway,
4
Department
of Radiology, University of California, San Diego,
California, United States,
5
Multi-Modal
Imaging Laboratory, University of California, San Diego,
California, United States,
6
Department
of Clinical Engineering, Haukeland University Hospital,
Bergen, Norway,
7
Department
of Neurosciences, University of California, San Diego,
California, United States,
8
Department
of Biological and Medical Psychology, University of
Bergen, Bergen, Norway
Electroconvulsive therapy (ECT) is by many clinicians
regarded as the most effective acute treatment of major
depressive disorder. At the group level, ECT has been
shown to induce structural changes in the hippocampus,
supporting a neurotrophic hypothesis. Here we
demonstrate that ECT-induced structural changes may be
appreciated at the level of the individual patient after
appropriate preprocessing and co-registration of
longitudinal intra-individual images. At the group level
(n=6; 3D T1 volumes at 3 time points) quantification
with FreeSurfer and Quarc, suggests structural changes
in various ROIs in the subcortical gray matter, in
addition to the hippocampus.
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