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Abstract #1352

Neurostructural correlates of NCAN, a genome-wide significant risk gene for psychiatric disorders

Harald Kugel 1 , Udo Dannlowski 2,3 , Dominik Grotegerd 2 , Ronny Redlich 2 , Janina Suchy 2 , Nils Opel 2 , Thomas Suslow 2,4 , Carsten Konrad 3 , Patricia Ohrmann 2 , Jochen Bauer 2 , Tilo Kircher 3 , Axel Krug 3 , Andreas Jansen 3 , Bernhard T Baune 5 , Walter Heindel 1 , Katharina Domschke 6 , Volker Arolt 2 , Christa Hohoff 2 , Marcella Rietschel 7 , and Stephanie H Witt 7

1 Department of Clinical Radiology, University of Mnster, Muenster, NRW, Germany, 2 Department of Psychiatry, University of Mnster, Muenster, NRW, Germany, 3 Department of Psychiatry, University of Marburg, Marburg, HE, Germany, 4 Department of Psychosomatic Medicine and Psychotherapy, University of Leipzig, Leipzig, SN, Germany, 5 Discipline of Psychiatry, University of Adelaide School of Medicine, Adelaide, SA, Australia, 6 Department of Psychiatry, University of Wrzburg, Wrzburg, BY, Germany, 7 Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, BW, Germany

Neurocan (NCAN) rs1064395 genotype is associated with psychiatric disorders as major depression, schizophrenia, and bipolar disorder. In risk allele (A) carriers, compared to carriers of the non-risk allele G, voxel based morphometry (VBM) revealed reduced gray matter volume in hippocampus and amygdala, in healthy volunteers as well as in major depression patients. We conclude that the increased risk for psychiatric disorder may be mediated by structural deficits in amygdala and hippocampus.

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