Inter-hemispheric functional and anatomical connectivity abnormalities in traffic accident-induced PTSD: a study combining fMRI and DTI
Yawen Sun 1 , Yan Zhou 1 , Wang Zhen 2 , Zhenyu Zhou 3 , Yong Zhang 3 , Jieqing Wan 4 , and Jianrong Xu 1
Department of Radiology, Ren Ji Hospital,
School of Medicine, Shanghai Jiao Tong University,
Shanghai, Shanghai, China,
Mental Health Center, Shanghai Jiao Tong University
School of Medicine, Shanghai, China,
Healthcare, Shanghai, China,
of Neurosurgery, Ren Ji Hospital, School of Medicine,
Shanghai Jiao Tong University, Shanghai, China
In this manuscript, we report the current study to
identify the possible alteration in inter-hemispheric
interactions in trauma-exposed victims who went on to
develop PTSD before diagnosis using resting-state fMRI
and diffusion tractography techniques. The victims with
PTSD exhibited an abnormal homotopic pattern with
decreased voxel-mirrored homotopic connectivity (VMHC)
in the superior/middle frontal gyrus before diagnosis.
Structural connectivity changes were in accordance with
the alterations in functional connectivity in corpus
callosum genu. Our results may be potential markers
showing predisposition towards developing PTSD.
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