Biophysical modeling of high field diffusion MRI demonstrates micro-structural aberration in Chronic Mild Stress (CMS) rat brain
Ahmad Raza Khan 1 , Andrey Chuhutin 1 , Brian Hansen 1 , Ove Wiborg 2 , Christopher D Kroenke 3 , and Sune Nrhj Jespersen 1
Center of Functionally Integrative
Neuroscience, Aarhus University, Aarhus, Denmark,
for Psychiatric Research, Aarhus University Hospital,
Advanced Imaging Research
Center, Oregon Health & Science University, Beaverton,
Oregon, United States
CMS is one of the leading causes of depression, but the
underlying pathology can be verified only by microscopy.
This study was performed on CMS model of rat to explore
sensitivity of diffusion weighted MRI to microstructural
alterations in different brain regions. We utilized
biophysical modelling and diffusion kurtosis (DKI)
imaging to characterize microstructural aberrations in
CMS brains. The study reveals significant increases in
neurite density and mean kurtosis, and significant
decreases in MD and extracellular diffusivity in the
prefrontal cortex. We conclude that biophysical
modelling and DKI modalities are able to detect
preclinical alterations in CMS brains.
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