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Abstract #1373

Different Epileptic Brain Networks in Unilateral Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis Identified by the Whole Brain Tract-Based Automatic and Surface-based Analyses

Yao-Chia Shih 1,2 , Yu-Jen Chen 2 , Yung-Chin Hsu 2 , Yu-Chun Lo 2 , Hong-Huei Liu 3 , and Wen-Yih Issac Tseng 2,4

1 Graduate Institute of Biomedical Engineering, National Taiwan University, Taipei, Taipei, Taiwan, 2 Center for Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taipei, Taiwan, 3 Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taipei, Taiwan, 4 Molecular Imaging Center, National Taiwan University, Taipei, Taipei, Taiwan

Unilateral mesial temporal lobe epilepsy (MTLE) with HS was regarded as a network disorder. In the present study, we proposed a surface-based analysis and a tract-specific analysis over the whole brain to detect, respectively, the GM and WM alterations in unilateral MTLE with HS. Since the sclerotic hippocampus may generate epileptic activities and spread via the WM tracts to other extratemporal regions, we hypothesized that the WM alterations due to MTLE with HS might affect the averaged cortical thickness of the connected GM regions. In addition, we assumed that left and right MTLE with HS should exhibit different epileptic networks. Using the surfaced-based analysis and TBAA method to assess, respectively, the WM and GM alterations over the whole brain, this work demonstrated different epileptic brain networks between left and right MTLE with HS.

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