Abstract #1387
Highly reproducible whole brain myelin water mapping with FAST-T2 in 4 minutes using geometric echo time sampling
Thanh D Nguyen 1 , Kofi Deh 1 , Sneha Pandya 1 , Elizabeth Monohan 1 , Ashish Raj 1 , Yi Wang 1 , and Susan A Gauthier 1
1
Weill Cornell Medical College, New York, NY,
United States
The objective was to develop fast and reproducible whole
brain myelin water mapping for longitudinal study of
multiple sclerosis. A 4 min Fast Acquisition with Spiral
Trajectory and T2prep (FAST-T2) sequence together with a
robust multi-voxel Spatially constrained Nonlinear
(SPAN) data fitting algorithm enabled highly
reproducible myelin water fraction measurements between
repeated scans (negligible bias with
2%
limits of agreement on a per voxel basis).
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