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Abstract #1390

The Influence of Surgical Correction on White Matter Microstructural Integrity in Rabbits with Familial Coronal Suture Craniosynostosis

Lesley M Foley 1 , Shinjini Kundu 2 , Wendy Fellows-Mayle 3 , T Kevin Hitchens 1,4 , Gustavo K Rohde 2 , Ramesh Grandhi 3 , Christopher M Bonfield 3 , and Mark P Mooney 5

1 Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, PA, United States, 2 Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, United States, 3 Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, United States, 4 Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, United States, 5 Department of Anthropology, University of Pittsburgh, Pittsburgh, PA, United States

Craniosynostosis is where one or more of the calvarial sutures fuse prematurely. This work examines microstructural integrity of white matter, using DTI. Rabbits were assigned to one of nine groups, wild type (WT), complete fusion of the coronal suture (BC), and surgically corrected (BC-SU) at 12, 25 or 42 days. As age increased neurophysiological differences between WT, BC, and BC-SU groups become more pronounced, especially in the corpus callosum, cingulum and fimbriae. Using a linear support vector machine classifier, classification into WT, BC, and BC-SU groups was possible with high accuracy. DTI revealed differences between craniosynostotic and surgically corrected animals.

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