Hippocampi and epilepsy in MS patients: a diffusion weighted imaging study with NODDI.
Alberto De Luca 1,2 , Marco Castellaro 1 , Stefania Montemezzi 3 , Massimiliano Calabrese 4 , and Alessandra Bertoldo 1
Department of Information Engineering,
University of Padova, Padova, PD, Italy,
of Neuroimaging, Scientific Institute, IRCCS "Eugenio
Medea", Bosisio Parini, LC, Italy,
Unit, Azienda Ospedaliera di Verona, Verona, Italy,
Section, Department Of Neurological and Movement
Sciences, University Hospital of Verona, Verona, Italy
Multiple Sclerosis (MS) population presents higher
prevalence of temporal lobe epilepsy than the healthy
population. In this work we investigate if the
combination of a multi-shell diffusion weighted
acquisition with the NODDI model can provide insights of
the differences between the hippocampi of epileptic and
non-epileptic subjects in a MS population. Results show
that while the fractional anisotropy index is not
statistically different, the NODDI derived quantities
ODI and Kappa reveal statistical differences in both the
left and right hippocampi, that appear to link epileptic
episodes with alterations of the fibers in these areas.
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