A novel Double Inversion Recovery MRI pulse sequence: improved lesion characterization for demyelinating WM and cortical lesions in Multiple Sclerosis?
Jan-Mendelt Tillema 1 , John Port 2 , Pascal Atanga 1 , Yunhong Shu 2,3 , Claudia Lucchinetti 1 , and Istvan Pirko 1
Neurology, Mayo Clinic, Rochester, MN,
Mayo Clinic, Rochester, MN, United States,
Engineering and Medical Physics, Mayo Clinic, Rochester,
MN, United States
In this study, a novel double inversion recovery pulse
sequence was applied in patients with Multiple
Sclerosis, suppressing signal from CSF and gray matter.
We show a new ring pattern of signal change surrounding
WM lesions that is not seen on standard DIR.
Approximately 50% of the identified lesions reveal this
rim pattern of hypo-intense signal change, most
prominent in larger and periventricular lesions.
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