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Abstract #1401

Brain temperature is elevated in relapsing-remitting relative to progressive multiple sclerosis

Victoria M Leavitt 1 , Alayar Kangarlu 2 , Feng Liu 2 , Claire S Riley 3 , and James F Sumowski 4

1 Columbia University Medical Center, New York, New York, United States, 2 New York State Psychiatric Institute, New York, New York, United States, 3 Columbia University Medical Center, New York, United States, 4 Kessler Foundation, New Jersey, United States

We hypothesize that elevated body and brain temperature in patients with relapsing-remitting multiple sclerosis (RRMS) indicates clinically-silent disease activity, i.e., inflammatory processes. MRS thermometry was used to measure brain temperature in RRMS and progressive-type MS patients. Brain temperature was elevated in RRMS patients relative to progressive-type patients. Monitoring brain and body temperature may allow us to detect clinically-silent inflammatory processes in patients with RRMS.

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