Detecting Iron Deposition In Multiple Sclerosis Using Susceptibility Contrast Imaging
Bing Yao 1,2 , Sarah Wood 1,3 , Zhiguo Jiang 4 , Glenn Wylie 1,2 , and John DeLuca 1,2
Rocco Ortenzio Neuroimaging Center, Kessler
Foundation, West Orange, NJ, United States,
of Physical Medicine & Rehabilitation, Rutgers
University, Newark, NJ, United States,
Department, Montclair State University, Montclair, NJ,
Performance Engineering Lab, Kessler Foundation, West
Orange, NJ, United States
Hypointensity of deep brain gray matter structures in
T2*-weighted images (T2WI) of multiple sclerosis (MS)
patients has been reported and suggested to represent
increased iron deposition. However, these findings are
difficult to generalize as the contrast in T2WI depends
on several MR parameters including TE, TR, and others.
Here, we explored using quantitative susceptibility
contrast imaging including R2* and quantitative
susceptibility map to identify characteristic regions
suggestive of increased iron deposition in MS patients.
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