Abstract #1411
Multimodal Imaging of Functional Alterations of the Thalamus Following Mild Traumatic Brain Injury
Chandler Sours 1,2 , Elijah George 1,2 , Steven Roys 1,2 , Jiachen Zhuo 1,2 , and Rao P Gullapalli 1,2
1
Diagnostic Radiology and Nuclear Medicine,
University of Maryland School of Medicine, Baltimore,
MD, United States,
2
Magnetic
Resonance Research Center, Baltimore, MD, United States
The aim of this study is to investigate the acute
functional alterations in the thalamus following mild
traumatic brain injury (mTBI) using resting state fMRI
(rs-fMRI) and magnetic resonance spectroscopy imaging
(MRSI). Results suggest that in addition to reduced
NAA/Cr in the thalamus, acute mTBI patients have
increased thalamo-cortical connectivity, including both
cortical areas associated with primary sensory
processing and cortical areas associated with the
Default Mode Network. These results provide evidence for
a functionally damaged thalamus in the initial days
following mTBI and may be associated with common post
concussive symptoms experienced by these patients.
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