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Abstract #1418

Comparison of DTI group analysis using non-linear and linear registration techniques

Blessy Mathew 1 , Wanyong Shin 1 , Mingyi Li 1 , Mark J. Lowe 1 , Sarah Banks 2 , Michael Phillips 1 , Michael T. Modic 1 , and Charles Bernick 2

1 Cleveland Clinic, Cleveland, OH, United States, 2 Cleveland Clinic, Las Vegas, Nevada, United States

From the longitudinal professional fighter's brain health study of active professional fighters, ROI based DTI result has been published to show the fight history or number of knock outs (NKO) predicts DTI changes in 74 of boxers and 81 mixed martial arts fighters (MMA). In this study, we ran voxel-wise DTI group analysis to replicate the previous finding from ROI analysis and to expand predefined ROIs to whole brain using linear and nonlinear registration methods. We conclude that, in a large cohort of subjects at risk for brain trauma, the non-linear technique is better at detecting group-level structural changes than the linear technique.

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