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Abstract #1421

Default-mode network functional connectivity progression in the days following a single sports concussion

Victoria L Morgan 1 , Andrew J Gregory 2 , and Allen K Sills 3

1 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 2 Ortho-Sports Medicine, Vnderbilt University, Nashville, TN, United States, 3 Neurosurgery, Vanderbilt University, Nashville, TN, United States

The purpose of this work is to quantify the functional brain network changes in college student-athletes within one week of a single sports concussion compared to healthy college students. The results show that within days of injury there were focal increases in functional connectivity (FC) in parts of the default-mode network (DMN) including the bilateral hippocampus, precuneus and ventromedial prefrontal cortex. The average FC across the whole DMN linearly increased over the first week, but eventually returned to the range of the healthy subjects in three subjects. Together these results suggest a progression of DMN FC impairment and recovery.

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