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Abstract #1423

Resting-State Functional Magnetic Resonance Imaging Connectivity and Behavioral Outcomes in Traumatic Brain Injury

Shiliang Huang 1 , Qiang Shen 1 , Lora Talley Watts 1 , Justin Alexander Long 1 , Wei Li 1 , and Timothy Q Duong 1

1 Research Imaging Institute, The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

Resting state functional MRI studies have reported disrupted functional connectivity after traumatic brain injury (TBI) in humans. The types, time after injury, extent and location of TBI in humans are heterogeneous. Animal models of TBI offer a means to study the effects of injury on rsfMRI under controlled conditions. The goal of this study was to use independent component analysis (ICA) method to investigate longitudinal changes of functional connectivity in moderate traumatic brain injury in rats. Comparisons were made with functional outcomes measured by forelimb placement asymmetry and foot fault behavioral tests.

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