T2, Diffusion, and Perfusion Abnormalities are associated with Impaired Cerebrovascular Reactivity in the Normal-appearing White Matter of Elderly Subjects with Leukoaraiosis.
Kevin Sam 1,2 , Boris Peltenburg 2 , Adrian P. Crawley 2 , Julien Poublanc 2 , Olivia Sobczyk 2 , Diem Pham 3 , David E. Crane 3 , Christopher J.M. Scott 3 , Alicia A. McNeely 3 , Daniel M. Mandell 2 , Joseph A. Fisher 1 , Sandra E. Black 3 , and David J. Mikulis 2
Department of Physiology, University of
Toronto, Toronto, Ontario, Canada,
of Medical Imaging, Toronto Western Hospital, Toronto,
Sciences Research Program, Sunnybrook Research
Institute, Toronto, Ontario, Canada
Cerebrovascular reactivity in the normal-appearing white
matter was assessed by using the BOLD MRI signal in
response to a consistently applied step change in the
arterial partial pressure of carbon dioxide. We examined
quatitative T2, diffusion, and perfusion maps in the
white matter and found subtle abnormalities in these
metrics that were associated with impaired
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