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Abstract #1481

How volume affects the pulmonary MRI signal: Investigations with 3D ultra-fast balanced Steady-State Free Precession

Orso Pusterla 1 , Oliver Bieri 1 , Gregor Sommer 2 , and Grzegorz Bauman 1

1 Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland, 2 Clinic of Radiology and Nuclear Medicine, Department of Radiology, University of Basel Hospital, Basel, Switzerland

3D ultra-fast balanced Steady-State Free Procession imaging - originally suggested for improved morphological chest imaging and visualization of the lung parenchyma and vasculature - was used for exploring the functional dependence between the pulmonary MRI signal and the lung's volume in healthy volunteers. It is demonstrated that the signal intensity in healthy volunteers can be empirically described by a non-linear function that scales inversely proportional with the lung volume. The suggested experimental protocol may be beneficial for patients with respiratory diseases, where a distorted signal intensity dependence on the lung volume may reflect pathological changes of the lung parenchyma.

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