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Abstract #1486

Hyperpolarized 129 Xe Dissolved-Phase MR Spectroscopy in Mice Changes with Lung Cancer Progression

Rohan S Virgincar 1 , Simone Degan 2,3 , Matthew S Freeman 4 , Mu He 5 , and Bastiaan Driehuys 3

1 Biomedical Engineering, Duke University, Durham, North Carolina, United States, 2 Center for Molecular and Biomolecular Imaging, Duke University, Durham, North Carolina, United States, 3 Radiology, Duke University Medical Center, Durham, North Carolina, United States, 4 Medical Physics Graduate Program, Duke University, Durham, North Carolina, United States, 5 Electrical and Computer Engineering, Duke University, Durham, North Carolina, United States

This study exploits the solubility of 129 Xe in tissues and associated chemical shifts to study pathological changes in the tissue microenvironment accompanying lung tumor formation in mice. We acquired hyperpolarized 129 Xe spectra from both the FID and after a spin echo. Spin echo spectra showed two unique peaks, belonging to aqueous media and fat. The fat peak was dramatically reduced and slightly broadened with increasing tumor burden, estimated from histology. This may be a signature of white adipose tissue browning, a hallmark of cancer-associated cachexia. 129 Xe MRI could thus provide a novel ionizing radiation-free tool to study cachexia.

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