Gas Uptake Measures on Hyperpolarized Xenon-129 MRI are Inversely Proportional to Lung Inflation Level
Kun Qing 1 , Nicholas J. Tustison 1 , Tallisa A. Altes 1 , Kai Ruppert 1,2 , Jaime F. Mata 1 , G. Wilson Miller 1 , Steven Guan 1 , Iulian C. Ruset 3,4 , F. William Hersman 3,4 , and John P. Mugler, III 1
University of Virginia, Charlottesville, VA,
Children's Hospital, OH, United States,
LLC, NH, United States,
of New Hampshire, NH, United States
Gas uptake measures from hyperpolarized xenon-129 MRI
show high sensitivity to alterations of lung function in
disease. Previous studies have shown a strong dependency
of these measures on lung inflation. The purpose of this
study was to investigate the quantitative relationship
between gas uptake measures and lung inflation level.
Through experiments in 12 healthy and 5 COPD subjects,
we found strong inverse relationships between gas uptake
(tissue-to-gas, RBC-to-gas and total
dissolved-phase-to-gas ratios) and lung inflation level.
These findings could be used to obtain normalized lung
function parameters that are independent of the lung
inflation level at which they were measured.
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