Meeting Banner
Abstract #1488

Gas Uptake Measures on Hyperpolarized Xenon-129 MRI are Inversely Proportional to Lung Inflation Level

Kun Qing 1 , Nicholas J. Tustison 1 , Tallisa A. Altes 1 , Kai Ruppert 1,2 , Jaime F. Mata 1 , G. Wilson Miller 1 , Steven Guan 1 , Iulian C. Ruset 3,4 , F. William Hersman 3,4 , and John P. Mugler, III 1

1 University of Virginia, Charlottesville, VA, United States, 2 Cincinnati Children's Hospital, OH, United States, 3 Xemed LLC, NH, United States, 4 University of New Hampshire, NH, United States

Gas uptake measures from hyperpolarized xenon-129 MRI show high sensitivity to alterations of lung function in disease. Previous studies have shown a strong dependency of these measures on lung inflation. The purpose of this study was to investigate the quantitative relationship between gas uptake measures and lung inflation level. Through experiments in 12 healthy and 5 COPD subjects, we found strong inverse relationships between gas uptake (tissue-to-gas, RBC-to-gas and total dissolved-phase-to-gas ratios) and lung inflation level. These findings could be used to obtain normalized lung function parameters that are independent of the lung inflation level at which they were measured.

This abstract and the presentation materials are available to members only; a login is required.

Join Here