Mapping 129 Xenon ADC of Radiation-Induced Lung Injury at Low Magnetic Field Strength Using a Sectoral Approach
Krzysztof Wawrzyn 1,2 , Alexei Ouriadov 1 , Elaine Hegarty 1 , Susannah Hickling 3 , and Giles Santyr 1,4
Imaging Research Laboratories, Robarts
Research Institute, London, Ontario, Canada,
of Medical Biophysics, Western University, London,
of Medical Physics, McGill University, Montreal, Quebec,
Peter Gilgan Centre for Research and Learning, The
Hospital for Sick Children, Toronto, Ontario, Canada
Early diagnosis of radiation-induced lung injury
following radiotherapy is critical for prevention of
permanent lung damage. MRI of the apparent diffusion
coefficient (ADC) of hyperpolarized xenon-129 gas shows
promise for early measurement of RILI. A UTE sequence
based on a pseudo non-Cartesian k-space trajectory (i.e.
Sectoral) is implemented at low field (0.07 T) for
efficient use of the non-renewable magnetization of
xenon-129. A pilot study demonstrated Sectoral ADC
mapping on healthy and 2-weeks post irradiated rats. A
significant correlation between ADC and mean linear
intercept from histology was observed and a separation
between the cohorts was observed with FWHM ADC.
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