Abstract #1494
Regional Mapping of Gas Uptake by Lung Tissue and Blood in Subjects with COPD using Hyperpolarized Xenon-129 MRI
Kun Qing 1 , Talissa A. Altes 1 , Y. Michael Shim 1 , Nicholas J. Tustison 1 , Kai Ruppert 1,2 , Chengbo Wang 1,3 , Jaime F. Mata 1 , G. Wilson Miller 1 , Steven Guan 1 , Iulian C. Ruset 4,5 , F. William Hersman 4,5 , and John P. Mugler, III 1
1
University of Virginia, Charlottesville, VA,
United States,
2
Cincinnati
Children's Hospital, OH, United States,
3
The
University of Nottingham Ningbo China, Zhejiang, China,
4
Xemed
LLC, NH, United States,
5
University
of New Hampshire, NH, United States
Hyperpolarized xenon-129 MRI is a useful tool to
characterize lung function in COPD. In this study, we
measured gas uptake of inhaled xenon-129 in 19 COPD
subjects and 21 healthy controls, and correlated the
results with xenon-129 ventilation, diffusion-weighted
imaging, pulmonary function tests and exercise tolerance
test. We found significant decrease of gas uptake and
different patterns of functional alternations in COPD
subjects as compared to healthy controls. The decrease
of gas uptake appeared to be mostly correlated with
emphysematous tissue destruction or enlargement of
distal airways detected by xenon-129 diffusion weighted
imaging, and not airflow obstruction.
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