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Abstract #1506

Anatomical Distribution of Fractional Ventilation and Oxygen Uptake Imaged by Multibreath Wash-in Helium-3 MRI in Human Subjects

Hooman Hamedani 1 , Stephen Kadlecek 1 , Yi Xin 1 , Hoora Shaghaghi 1 , Sarmad Siddiqui 1 , Milton Rossman 2 , and Rahim R. Rizi 1

1 Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2 Medicine, University of Pennsylvania, Philadelphia, PA, United States

The suite of imaged fractional ventilation and oxygen tension may provide a useful diagnostic tool for the detection and monitoring of subclinical smoking-related alterations in lung function. Both fractional ventilation and oxygen uptake gravity gradients successfully differentiated between healthy non-smoker, asymptomatic smoker, and COPD subjects. The results in asymptomatic smokers also indicate that cigarette smoke induces changes in the lung that are not being captured by the clinical tests.

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