Abstract #1509
2D localized COSY for the quantification of omega-3 PUFA content in oil phantoms and in vivo in rat liver
Sharon Janssens 1 , Marina D.B. Sabbadini 1 , Klaas Nicolay 1 , and Jeanine J. Prompers 1
1
Biomedical NMR, Eindhoven University of
Technology, Eindhoven, Noord-Brabant, Netherlands
Fatty liver disease is associated with marked changes in
liver lipid composition, i.e. increases in saturated
fatty acids and decreases in omega-3 polyunsaturated
fatty acids (PUFA). Currently available methods to
determine liver lipid composition require a biopsy. The
aim of this study was to develop a 2D MRS method for
in
vivo
detection
of omega-3 PUFA based on localized correlation
spectroscopy (L-COSY). We demonstrate the specific and
quantitative detection of omega-3 PUFA with 2D L-COSY in
oil phantoms and the feasibility to perform L-COSY
in
vivo
in
liver. However, in rat liver omega-3 PUFA content was
below the detection limit.
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