Abstract #1512
Oral Lipid Challenge: The Effects of Saturated Fat on Hepatic Gluconeogenesis, ATP Production, and Fat Accumulation in Healthy Humans
Paul Begovatz 1 , Sabine Kahl 1,2 , Peter Nowotny 1 , Bettina Nowotny 1,2 , and Michael Roden 1,2
1
Leibniz Center for Diabetes Research at
Heinrich Heine University, Institute for Clinical
Diabetology, German Diabetes Center, Dsseldorf,
Germany,
2
University
Hospital, Department of Endocrinology and Diabetology,
Dsseldorf, Germany
Healthy male volunteers (n=14, Age 25.65.3 yr, BMI of
22.51.1 kg/m
2
) ingested a 1.20.1 g/(kg body
weight) bolus of palm oil or placebo during a 20-hr
fast.
13
C-MRS
liver glycogen measurements revealed decreased rates of
net glycogen breakdown, and increased gluconeogenesis
during oil intervention compared to placebo. Palm oil
intervention also led to increased rates of lipid
oxidation (indirect calorimetry), and increased hepatic
ATP production (
31
P-MRS, 3D ISIS), and liver
fat (single voxel
1
H-MRS).
This provides evidence that a single oral bolus of
saturated fat leads to increased gluconeogenesis through
free fatty acid oxidation and ATP production in healthy
subjects.
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