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Abstract #1517

Dual echo, PDFF and mDIXON compared to 1 H-MRS for fat fraction estimation: only PDFF can accurately measure low fat fractions.

Jurgen Henk Runge 1 , Ulrich H Beuers 2 , Aart J Nederveen 1 , and Jaap Stoker 1

1 Radiology, Academic Medical Center, Amsterdam, Noord-Holland, Netherlands, 2 Gastroenterology & Hepatology, Academic Medical Center, Amsterdam, Noord-Holland, Netherlands

Accurate and reproducible liver fat fraction (FF) estimation is important. 1 H-MRS is the MR reference standard but has certain drawbacks, some of which are resolved by imaging-based FF estimation. The standard mDIXON acquisition allows high-resolution water (W) and (F) image reconstruction, but its FA and short TR, induce T 1 -weighting, causing over-estimation of low FF. We compared dual echo, mDIXON and proton density fat fraction (PDFF) with 1 H-MRS in fatty liver disease patients. mDIXON had non-zero lower limit, i.e. over-estimation of low FF: standard mDIXON images should not be used for FF mapping. PDFF compared best to 1 H-MRS and is preferable.

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