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Abstract #1570

Visualization of Lupus Nephritis using SPIO

Ting Chen 1,2 , Yuki Mori 1,2 , Zhenyu Cheng 1,2 , Soyoung Lee 1 , Kai Wang 1 , Barry Ripley 1 , Tadamitsu Kishimoto 1 , Chizuko Inui-Yamamoto 1,2 , Fuminori Sugihara 1 , Noriko Kitagaki 1 , Yoshiyuki Tago 3 , Shinichi Yoshida 3 , Kohji Ohno 4 , and Yoshichika Yoshioka 1,2

1 Immunology Frontier Research Center (IFReC), Osaka University, Suita, Osaka, Japan, 2 Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology (NICT) and Osaka University, Suita, Osaka, Japan, 3 Biotechnology Development Laboratories, Kaneka Corporation, Takasago, Hyogo, Japan, 4 Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan

a new contrast agent containing anti-Sm antibody was generated for visualizing the Lupus Nephritis in-vivo,the specific distribution pattern of it in the renal corpuscle may reflect the symptoms of kidney disease in SLE model mice, and it also showed us the possibility of diagnosing the SLE by this new particle.

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