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Abstract #1593

Brown Adipose Tissue Thermometry in the Paraventricular Specific Knock-out Mouse Model at 15.2T

Myriam Diaz Martinez 1 , Henry H Ong 1 , Masoud Ghamari-Langroudi 2 , Aliya Gifford 1,3 , Roger Cone 2 , and E Brian Welch 1

1 Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 2 Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, United States, 3 Physical and Chemical Biology Program, Vanderbilt University Medical Center, Nashville, TN, United States

Direct and non-invasive measurements of brown adipose tissues (BAT) temperature is crucial for understanding its role in thermoregulation in the mouse. We have implemented a novel fat-water MRI (FWMRI) method with explicit modeling of temperature which is dependent on the water frequency offset to estimate the interscapular BAT temperature at thermoneutral environment in the Paraventricular (PVN) specific knock-out mouse model, at ultra high field (15.2T) using the Bruker CryoProbe surface coil with 2D FLASH sequence, with multi-interleaved echo count. Our results demonstrate the potential of MRI to detect subtle changes in temperature of brown adipose tissue in mice.

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