Safeguarding the Family Jewels: Using MRI to Monitor for Testicular Toxicity
Denise Welsh-McCracken 1 , Yvonne Van Gessel 1 , Dierdre Scully 2 , Jacob Hesterman 2 , and Paul J McCracken 1
Eisai, Andover, MA, United States,
Boston, MA, United States
Drug induced testicular toxicity creates a potential
obstacle to moving promising new therapies into clinical
trials. We investigate the utility MRI for detecting and
monitoring testicular toxicity in a rat pilot study.
Mild toxicity was induced in mature male SD rats using
1,3 Dinitrobenzene (35mpk po). Rats were imaged on days
0, 3,5, and 15. T2-weighted image data were bias-field
corrected and manually segmented to isolate the testes
signal. 2D fast Fourier transform (FFT) was used to map
data to the spatial frequency domain. Fourier analysis
revealed decreased group average AUCs at days 3 and 5,
reaching significance at day15.
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