B0 inhomogeneity correction of T2* from fat-water MRI: application to a diet-induced obesity mouse model at 15.2T
Henry H. Ong 1,2 , Corey D. Webb 3 , Marnie L. Gruen 3 , Alyssa H. Hasty 3 , John C. Gore 1,2 , and E. Brian Welch 1,2
Vanderbilt University Institute of Imaging
Science, Nashville, TN, United States,
and Radiological Sciences, Vanderbilt University,
Nashville, TN, United States,
Physiology and Biophysics, Vanderbilt University School
of Medicine, Nashville, TN, United States
Previously, we investigated the potential of T2*
estimated from quantitative fat-water MRI (FWMRI) as a
marker of adipose tissue inflammatory changes due to
adipocyte iron overload in an established diet-induced
obesity mouse model at 15.2T. Preliminary results
indicated presence of large background B0 variations
(50-250 Hz/mm) that could adversely affect T2* mapping.
Here, we implement a recently proposed B0 variation
correction of FWMRI data. Using a subset of our previous
data, we show feasibility of this correction method for
in vivo mouse data at 15.2T. The correction primarily
affects T2* and not fat-signal-fraction or
in agreement with previous reports.
This abstract and the presentation materials are available to members only;
a login is required.