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Abstract #1637

Targeting Effects on the Volume and Gray-To-White-Matter Ratio of the Focused-Ultrasound Induced Blood-Brain Barrier Opening in Non-Human Primates In Vivo

Maria Eleni Karakatsani 1 , Gesthimani Samiotaki 1 , Matthew Downs 1 , Vincent Ferrera 2 , and Elisa Konofagou 1,3

1 Department of Biomedical Engineering, Columbia University, New York, NY, United States, 2 Department of Neuroscience, Columbia University, New York, NY, United States, 3 Department of Radiology, Columbia University, New York, NY, United States

The application of focused ultrasound (FUS) coupled with the systemic administration of microbubbles has been proved to open the Blood-Brain Barrier locally, transiently and non-invasively in non-human primates. This study provides evidence for a linear correlation between the incidence angle, the FUS pressure and the induced opening size. The parametric optimization of the experimental setup inducing the desired opening and the reproducibility of the experiment are achieved. Results also indicate that the opening-to-targeting-shift is gray-to-white-matter ratio dependent. For both tasks 3D T1 weighted pre- and post-contrast images were acquired based on which an automated intensity-based algorithm was designed.

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