Comparison of Multi-contrast MRI for Characterization of Irreversible Electroporation Ablation Zones in a Pig Liver Model with Histopathologic Correlation
Isabel Dregely 1 , Kyung Sung 1 , Ferdnand Osuagwu 1 , Dong Jin Chung 1 , Charles Lassman 2 , David Lu 1 , and Holden H Wu 1
Radiological Sciences, University of
California Los Angeles, Los Angeles, CA, United States,
and Laboratory Medicine, University of California Los
Angeles, Los Angeles, CA, United States
Irreversible electroporation (IRE) is a new technique
for minimally invasive local tissue ablation.
Multi-contrast MRI has potential to non-invasively
monitor IRE procedures. The purpose of this study was to
evaluate multi-contrast (T2w, T1w pre and post contrast
agent, and diffusion weighted imaging (DWI)) MRI for
characterizing tissue ablation zones created by
irreversible electroporation (IRE) in normal pig liver
and correlate with histopathology. We found that IRE
ablation zones were clearly visualized with multiple MRI
contrasts and lesion short axis from both T2w and T1w
MRI were correlated with pathology.
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